This comprehensive guidance document for lab management and operations was created by Sangita K. Jindal Ph.D. as part of her work on the ASRM practice committee and published in August 2022. It is an update to a previous document from 2008 and is used nationally by all IVF labs as best practice guidance for lab operations, quality control, lab staffing and qualifications, and staffing volumes to ensure patient safety and optimal patient care.