Peterson A, Wu H, Kappy M, Kucherov A, Singh M, Lieman H, Jindal S. Fertility and Sterility 121:291-8, 2024. PMID: 37952915.
WHY WAS THIS STUDY CONDUCTED?
To determine whether body mass index (BMI) was associated with live birth in patients undergoing transfer of frozen thawed preimplantation genetic testing for aneuploidy (PGT-A) embryos.
KEY FINDINGS
A normal-weight BMI range of 23–24.99 kg/m2 was associated with the highest probability of clinical pregnancy and live birth after a frozen-thawed PGT-A–tested blastocyst transfer in both autologous and donor recipient cycles. A BMI outside the range of 23–24.99 kg/m2 is likely associated with a malfunction in the implantation process, which is presumed to be related to a
uterine factor and not an oocyte factor, as both autologous and donor recipient cycle outcomes were associated similarly with the BMI of the intended parent.
WIDER IMPLICATIONS OF THE FINDINGS
The impact of obesity on pregnancy requires further investigation because some factors, such as duration, comorbid conditions, and severity, may be more likely to result in poor pregnancy outcomes. As such, future research is necessary to determine what medical treatment or lifestyle changes may benefit reproductive aged women with BMIs outside the normal range.