Gerber RS, Kappy M, Gingold J, Wu H, Lieman H, Singh M, Pollack S, Jindal S. Obstetrics and Gynecology 143:92-100, 2024. PMID: 37944144.
WHY WAS THIS STUDY CONDUCTED?
To compare obstetric and neonatal out comes after single embryo transfer (SET) compared with multiple embryo transfer (MET) from frozen-thawed transfer cycles of embryos that underwent pre implantation genetic testing for aneuploidies (PGT-A).
KEY FINDINGS
Despite some improvement in live birthrate, nearly half of the pregnancies that resulted from MET of embryos that underwent PGT-A were multiples. Compared with SET, MET is associated with significantly higher rates of neonatal morbidity, including preterm delivery and low birth weight.
WIDER IMPLICATIONS OF THE FINDINGS
The transfer of more than one embryo that underwent PGT-A should continue to be strongly discouraged, and patients should be counseled on the significant potential for adverse outcomes.