Gingold J, Kucherov A, Fazzari M, Lieman H, Ball GD, Doody K, Jindal S. Fertility and Sterility 123:50-60, 2025. PMID: 39128672.
WHY WAS THIS STUDY CONDUCTED?
To evaluate the impact of preimplantation genetic testing for aneuploidy (PGT-A) on first transfer live birth rate (LBR) and cumulative LBR (CLBR) in donor oocyte in vitro fertilization (IVF) cycles.
KEY FINDINGS
Preimplantation genetic testing for aneuploidy in fresh oocyte donor cycles was associated with decreased LBR and CLBR, whereas effects on frozen-thawed oocyte donor cycles were clinically negligible. Obstetric benefits associated with PGT-A in fresh donor cycles appear linked to increased single embryo transfer.
WIDER IMPLICATIONS OF THE FINDINGS
Given the reduced first transfer LBR and CLBR in association with PGT-A in fresh donor oocyte cycles despite increased two-pronuclear embryo availability, use of PGT-A in fresh oocyte cycles should be undertaken with significant caution.