Kahn J, Wu H, Gerber R, Shah T, Lieman H, Pollack SE, Singh M, Jindal S. Human Reproduction 39:1504-11, 2024. PMID: 38783613.
WHY WAS THIS STUDY CONDUCTED?
After an IVF cycle cancellation, does changing the stimulation protocol affect the odds of live birth and recurrent cancellation in the subsequent cycle?
KEY FINDINGS
Using a large national registry, patients with a first autologous IVF cycle that resulted in a cycle cancellation and was followed by a second autologous cycle within the study period, were included. Changing the protocol in the second cycle resulted 14% lower odds of recurrent cycle cancellation and 17% higher odds of live birth after fresh transfers. There was an increase in live birth when switching from antagonist to agonist suppression and from agonist suppression to antagonist compared to those who repeated their same stimulation protocol.
WIDER IMPLICATIONS OF THE FINDINGS
After IVF cycle cancellation, compared to those who repeated the same stimulation protocol, those who changed their protocol had higher odds of live birth and lower odds of recurrent cycle cancellation.